Center for Bioinformatics &
Genome Biology

Claudia Lefimil

clefimil@med.uchile.cl

56-2-978-6073
56-2-735-5580

Laboratory of Molecular Bacterial Genetic.
Program of Cellular and Molecular Biology.
Medicinal school . University of Chile.
Independencia 1027. Casilla 70086.
Santiago, Chile.

Present Position: Doctoral student - Biotechnology, Andrés Bello University.

Research Interests:

• Functional Genomics.
• Bioinformatics.
• Molecular Bacterial Genetics.

• Licenciate in Biochemistry. University of Concepción. August 1998.



• Professional Degree of Biochemistry. University of Concepción. March 2001.



• Doctoral student in Biotechnology,Andrés Bello University, 2006.

• Publications :

• Gnecco S., Pooley A., Lefimil C., Pino C. y L. Valenzuela. Chlorination of low-molecular-weight Euphorbia lactiflua natural rubber. 1997. Polymer Bulletin. 39: 605-612 [Abstract]
  
  
  
• Salazar J., Zuñiga R., Lefimil C., Söll D. and O. Orellana. Conserved aminoacids near the carboxy terminus of bacterial tyrosyl-tRNA synthetase are involved in tRNA and Tyr-AMP binding. 2001. FEBS Letters 491: 257-260. [Abstract] [Full text]
  
  
• Núñez H., Lefimil C., Min B., Soll D. and O. Orellana. In vivo formation of Glutamyl-tRNAGln in Escherichia coli by heterologous Glutamyl-tRNA synthetases. 2004. FEBS Letters 557, 133-135. [Abstract] [Full text]
  
  
• Quatrini R, Lefimil C, Holmes DS, Jedlicki E. The Ferric Iron Uptake Regulator (Fur) from the Extreme Acidophile Acidithiobacillus ferrooxidans, Microbiology 151(Pt 6):2005-15. 2005. [Abstract] [Full text]
  
  
• Quatrini R, Appia-Ayme C, Denis Y, Ratouchniak J, Veloso F, Valdés J, Lefimil C, Silver S, Roberto F, Orellana O, Denizot F, Jedlicki E, Holmes DS & Bonnefoy V. Global analysis of the ferrous iron and sulfur energetic metabolism of Acidithiobacillus ferrooxidans by microarray transcriptome profiling, pp 761-771 in: Proc. 16th International Biohydrometallurgy Symposium, Cape Town, South Africa, Eds S. Harrison, D Rawlings and J. Peterson, 2005.
  
  
• Appia-Ayme C, Quatrini R, Denis Y, Denizot F, Silver S, Roberto F, Veloso F, Valdés J, Cárdenas JP, Esparza M, Orellana O, Jedlicki E, Bonnefoy V & Holmes DS. Insights Into The Central Carbon Metabolism Of Acidithiobacillus ferrooxidans Revealed By Bioinformatic And Microarray Analysis, pp 753-760 in: Proc. 16th International Biohydrometallurgy Symposium, Cape Town, South Africa, Eds S. Harrison, D Rawlings and J. Peterson, 2005.
  
  
• Gnecco S., Pooley A., Krause M., Lefimil C., Pino C. y L. Valenzuela. Modificación química de la goma natural de Euphorbia lactiflua: análisis global. XXII Chilean Congress of Chemistry. 1997. Puyehue.
  
  
• Salazar J., Zuñiga R., Tapia J., Lefimil C. y Orellana O. Identificación de aminoácidos que participan en la interacción entre la tirosil-tRNA sintetasa y el tRNAtyr. XXI Annual meeting of the Society of Biochemistry of Chile. 1998. Valdivia.
  
  
• Salazar J., Zuñiga R., Lefimil C. y Orellana O. Peculiaridades de la tirosil y triptofanil tRNA sintetasas de Thiobacillus ferrooxidans. XLII Reunión Anual de la Sociedad de Biología de Chile. 1999. Pucón. Chile.
  
  
• Salazar J., Lefimil C., Zúñiga R., Söll D y Orellana O. En Acidithiobacillus ferrooxidans existen dos glutamil-tRNA sintetasas, una discriminante y otra no discriminante. XLV Annual meeting of the Society of Biology of Chile. 2002. Osorno. Chile.
  
  
• Lefimil C., Veloso F., Jedlicki E. y Holmes D. Anotación y análisis del genoma de Acidithiobacillus ferrooxidans. XLV Annual meeting of the Society of Biology of Chile. 2002. Osorno. Chile.
  
  
• Holmes D., Quatrini R., Valdés J., Veloso F., Riadi G., Barreto M., Rivas M., Lefimil C y E. Jedlicki. Biología Molecular de las bacterias lixiviantes. XXV Chilean Congress of Microbiology. 2003. Antofagasta. Chile.
  
  
• Holmes D., Quatrini R., Valdés J., Veloso F., Riadi G., Barreto M., Rivas M., Lefimil C. y E. Jedlicki. Partial metabolic reconstruction of the extremophile Acidithiobacillus ferrooxidans based on genome analysis. XLVI Annual meeting of the Society of Biology of Chile. 2003. Puyehue. Chile.
  
  
• Valdés J., Baretto M., Esparza M., Lefimil C., Osorio H., Quatrini R., Rivas M., Veloso F., Jedlicki E. and Holmes D. Metabolic Reconstruction of Acidithiobacillus ferrooxidans and Comparative Genomics of Associated Extremophiles. 2004. Worshop of Bioinformatics. Universidad de Talca. Chile.
  
  
• Quatrini R., Veloso F., Lefimil C., Osorio H., Esparza M., Jedlicki E. Y Holmes D. Genomics Insights into Iron Uptake and Homeostasis in the Biomining Microorganism Acidithiobacillus ferrooxidans. 2004. XXVI Chilean congress of Microbiology. Valparaíso. Chile.
  
  
• Raquel Quatrini, Corinne Appia-Ayme, Yann Denis, Jeanine Ratouchniak, Felipe Veloso, Jorge Valdes, Claudia Lefimil, Simon Silver, Frank Roberto, Omar Orellana, François Denizot, Eugenia Jedlicki, David Holmes and Violaine Bonnefoy. Global analysis of the ferrous iron and sulfur energetic metabolism of Acidithiobacillus ferrooxidans by microarrays transcriptome profiling, pp 141-142, in Abstracts, eds S. T. L. Harrison, D. E. Rawlings and J. Peterson, 16th. International Biohydrometalurgy Congress, Cape Town, South Africa, 25-29 Sept., 2005.
  
  
• Corinne Appia-Ayme, Raquel Quatrini, Yann Denis, François Denizot, Simon Silver, Frank Roberto, Felipe Veloso, Jorge Valdes, Claudia Lefimil, Omar Orellana, Eugenia Jedlicki, Violaine Bonnefoy and David Holmes. Microarray Analysis of Gene Expression in Acidithiobacillus ferrooxidans: Insights into its Central Metabolism and Regulatory Networks, pp138-140, in Abstracts, eds S. T. L. Harrison, D. E. Rawlings and J. Peterson, 16th. International Biohydrometalurgy Congress, Cape Town, South Africa, 25-29 Sept., 2005.
  
  
• Holmes, D. S., Valdés, J.,Baretto, M., H.,Quatrini, R., Veloso, F., L’Heureaux, T.,Chacón, M.,Santa Ana, M., Pedroso I., Cárdenas J-P., Lefimil, C., Esparza, M., Osorio, Rivas, M., Rios, C., Herrera, J. and Jedlicki, E. The Genome of Acidithiobacillus ferrooxidans Reveals Insights into its Unusual Physiology. 2005. Symposium on Bacterial Genomics. XLVIII Annual meeting of the Society of Biology, Pucón, Chile.
  
  
• Valdés, Jorge, Marlen Baretto, Claudia Lefimil, Hector Osorio, Raquel Quatrini, Mariella Rivas, Felipe Veloso, Theresa L’Heureaux, Inti Pedroso, Eugenia Jedlicki and David S. Holmes. Whole Genome Identification of Metabolic and Regulatory Pathways in Acidithiobacillus ferrooxidans. 2005. 3rd Workshop of Bioinformatics, Santiago, Chile.
  
  

CC - [Amir S. 2006] - [ Last update 03/23/2007 ]